by Heidi Hehnly in Papers
Check out our new preprint up on BioRxiv here: https://www.biorxiv.org/content/10.1101/2022.01.09.475500v1
Titled: Pericentriolar matrix integrity relies on cenexin and Polo-Like Kinase (PLK)1
Model of mitotic centrosome protein disruption with cenexin loss.
by Heidi Hehnly in Papers, News
Check out Nikhila’s paper titled “Rab11 endosomes coordinate centrosome number and movement following mitotic exit” here. Its got cool new stuff linking endosomes with centrosomes during the last stage of cell division, the cleavage of the cytokinetic bridge. This was done in collaboration with the Patteson lab.
Model depicting centrosomes (green) containing Rab11-endosomes (orange) reorienting towards the cytokinetic bridge with associated middy (purple) during pre-abscission.
by Heidi Hehnly in Papers
Congrats to Julia Riley, Amber K. Rusnock, and the Castaneda Lab, along with Hehnly lab member Peter Fioramonti on the recently accepted manuscript! Check it out here: https://onlinelibrary.wiley.com/doi/10.1111/jnc.15453. It’s titled “ALS-linked mutations impair UBQLN2 stress-induced bimolecular condensate assembly in cells”. I even helped out with some image processing (see below)!
by Heidi Hehnly in Papers, News
Check out a fun write-up by Hehnly Lab undergraduate turned post-bac, Nicole Hall, about a substructure of the centrosome, sub-distal appendages contribution to cell division, ciliogenesis, and differentiation. Also importantly, Nicole is on the look out for sweet graduate programs, she is the catch of the decade for any lab who wants an excited, curious, and driven graduate student. Keep your eyes peeled for great things in the future from Nicole!
The title of her paper is: A centriole’s Subdistal appendages: contributions to cell division, ciliogenesis and differentiation
You can find it here.
Appendage proteins result in cilia defects and/or spindle positioning defects with downstream consequences in development.